Antimicrobial stewardship interventions in least developed and low-income countries: a systematic review protocol

Introduction Antimicrobial resistance (AMR) is increasing in low resource settings. It complicates the management of infectious diseases and an cause death. This due to, among other things, lack health resources for appropriate diagnosis unregulated access to antimicrobials public sphere. Developing context-specific interventions that enable judicious use important curb this problem. Methods We will conduct a systematic review antimicrobial stewardship (AMS) approaches Development Assistance Committee least developed low-income countries. The inclusion criteria are hospitalised patients all age groups exclusion community-based trials studies solely focus on viral, fungal or parasite infections. be classified as structural, enabling, persuasive, restrictive combined. Outcomes included clinical, microbiological behavioural outcomes. randomised controlled trials, before–after studies, interrupted time series cohort qualitative studies. Data extracted using forms adapted from Cochrane collaboration data collection form. conducted according Preferred Reporting Items Systematic Reviews Meta-Analyses guidelines risk bias done Integrated quality Criteria Review Multiple Study Designs. Ethics dissemination Our findings presented clinicians policymakers, support developing AMS protocols publish our results peer-reviewed journals. Trial registration number CRD42020210634.